Synthesis and biological activity evaluation of new functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazoles

Abstract

New functionally substituted 5-arylidene-2,4-dioxotetrahydro-1,3-thiazole-3-carboxylic acid cholesteryl esters were synthesized from 2,4-dioxotetrahydro-1,3-thiazole and evaluated for their in vitro cytotoxicity against several human tumor cell lines and one normal lung fibroblast cell line.

Keywords

• heterocycles
• synthesis
• 5-arylidene-2
• 4-dioxotetrahydro-1
• 3-thazole-3-carboxylic acid cholesteryl esters
• in vitro cytotoxicity