Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Abstract

Yun’an Qing,1 Lin Cheng,2 Ruiyan Li,1 Guancong Liu,1 Yanbo Zhang,1 Xiongfeng Tang,1 Jincheng Wang,1 He Liu,1 Yanguo Qin1 1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China Abstract: Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized. Keywords: antibacterial mechanism, biocompatibility, osteogenic-related cells, orthopedic implants, silver nanoparticles, surface modification

Keywords

• Antibacterial mechanism
• Biocompatibility
• Osteogenic related cells
• Orthopedic implants
• Silver nanoparticles
• Surface modification