Interatrial shunt devices for heart failure with normal ejection fraction: a technology update

Abstract

Joseph J Cuthbert, Pierpaolo Pellicori, Andrew L Clark Department of Cardiology, Hull York Medical School, Hull and East Yorkshire Medical Research and Teaching Centre, Castle Hill Hospital, Cottingham, Kingston upon Hull, UK Abstract: Heart failure with normal ejection fraction (HeFNEF) accounts for ~50% of heart failure admissions. Its pathophysiology and diagnostic criteria are yet to be defined clearly which may hinder the search for effective treatments. The clinical hallmark of HeFNEF is exertional breathlessness, often due to an abnormal increase in left atrial pressure during exercise. Creation of an interatrial communication to offload the left atrium is a possible therapeutic approach. There are two percutaneously delivered devices currently under investigation which are discussed in this review. Keywords: IASD, V-Wave, device therapy, HeFNEF, review, preserved EF, HeFPEF, HFpEF

Keywords

• Heart failure with normal ejection fraction. Heart failure with normal ejection fraction. Interatrial shunt devices. IASD. V-Wave. Device therapy.