IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

Qingxiao Song; Xiaoning Wang; Xiwei Wu; Tae Hyuk Kang; Hanjun Qin; Dongchang Zhao; Robert R. Jenq; Marcel R. M. van den Brink; Arthur D. Riggs; Paul J. Martin; Yuan-Zhong Chen; Defu Zeng

doi:10.1038/s41467-021-21133-3

Nature Communications (Feb 2021)

IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

Qingxiao Song,
Xiaoning Wang,
Xiwei Wu,
Tae Hyuk Kang,
Hanjun Qin,
Dongchang Zhao,
Robert R. Jenq,
Marcel R. M. van den Brink,
Arthur D. Riggs,
Paul J. Martin,
Yuan-Zhong Chen,
Defu Zeng

Affiliations

Qingxiao Song: Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope
Xiaoning Wang: Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope
Xiwei Wu: Department of Integrative Genomics Core, The Beckman Research Institute of City of Hope
Tae Hyuk Kang: Department of Integrative Genomics Core, The Beckman Research Institute of City of Hope
Hanjun Qin: Department of Integrative Genomics Core, The Beckman Research Institute of City of Hope
Dongchang Zhao: The Tisch Cancer Institute and Division of Hematology/Medical Oncology, The Icahn School of Medicine at Mount Sinai Hospital
Robert R. Jenq: Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, University of Texas MD Anderson Cancer Center
Marcel R. M. van den Brink: Department of Medicine, Adult Bone Marrow Transplant Service, Memorial Sloan Kettering Cancer Center
Arthur D. Riggs: Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope
Paul J. Martin: Fred Hutchinson Cancer Research Center, University of Washington
Yuan-Zhong Chen: Fujian Medical University Center of Translational Hematology, Fujian Institute of Hematology, and Fujian Medical University Union Hospital
Defu Zeng: Diabetes and Metabolism Research Institute, The Beckman Research Institute of City of Hope

DOI: https://doi.org/10.1038/s41467-021-21133-3
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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Pathogenesis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) remains unclear., Here the authors show in mouse models that dysbiosis caused by the expansion of Th/Tc22, as well as depletion of CX3CR1hi mononuclear phagocytes resulted from the reduction of Th/Tc1, contributes to SR-Gut-aGVHD onset.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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