Histone lactylation-related genes correlate with the molecular patterns and functions of cancer-associated fibroblasts and have significant clinical implications in clear cell renal cell carcinoma
Weiyu Kong,
Jiaxin He,
Qinyao Zhou,
Xin Zhou,
Xiyi Wei,
Yonglin Yang,
Yiwen Mei,
Shuai Wang,
Xi Zhang,
Bing Yao,
Yulin Yue,
Jiali Xu,
Minjun Jiang,
Chen Xu
Affiliations
Weiyu Kong
Department of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, 215000, China; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
Jiaxin He
National Experimental Teaching Center of Basic Medical Science, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China
Qinyao Zhou
National Experimental Teaching Center of Basic Medical Science, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China
Xin Zhou
National Experimental Teaching Center of Basic Medical Science, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China
Xiyi Wei
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
Yonglin Yang
The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou School of Clinical Medicine, Nanjing Medical University, Taizhou, China
Yiwen Mei
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
Shuai Wang
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
Xi Zhang
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
Bing Yao
National Experimental Teaching Center of Basic Medical Science, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China
Yulin Yue
Department of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, China; Corresponding author.
Jiali Xu
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Corresponding author.
Minjun Jiang
Department of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, 215000, China; Corresponding author.
Chen Xu
Department of Urology, Suzhou Ninth People's Hospital, Soochow University, Suzhou, 215000, China; Corresponding author.
Recent research emphasised the indispensable role of histone lactylation in the activation of hepatic stellate cells. The VHL mutation is extremely common in clear cell renal cell carcinoma, which normally causes a metabolic shift in cancer cells and increases lactate production, eventually creating a lactate-enriched tumour microenvironment. Cancer-associated fibroblasts (CAFs) promote tumour progression, which is also vital in clear cell renal cell carcinoma. Therefore, this study investigated histone lactylation in CAFs and its impact on patient survival. Multiomics technology was employed to determine the role of histone lactylation-related genes in the evolution of CAFs which correlated with the function and molecular signatures of CAFs. The results suggested that TIMP1 was the hub gene of histone lactylation-related genes in clear cell renal cell carcinoma.
