Study on trophoblast cell-surface antigen 2 gene and triple-negative breast cancer

Abstract

Trophoblast cell-surface antigen 2(Trop2) gene plays an important role in the development of various malignant tumors. Trop2 gene regulates the expression of cyclin D1 and E-cadherin in triple-negative breast cancer (TNBC), and promote the metastasis and invasion of TNBC. In this study, the structure, function, mechanism of action, the expression of Trop2 gene and treatment of TNBC were reviewed to find therapeutic targets for TNBC and explore new therapy.

Keywords

• |triple-negative breast cancer|trop2 gene|targeted therapy