Nature Communications (Apr 2020)
TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism
- Jie Cheng,
- Yan Huang,
- Xiaohui Zhang,
- Yue Yu,
- Shumin Wu,
- Jing Jiao,
- Linh Tran,
- Wanru Zhang,
- Ran Liu,
- Liuzhen Zhang,
- Mei Wang,
- Mengyao Wang,
- Wenyu Yan,
- Yilin Wu,
- Fangtao Chi,
- Peng Jiang,
- Xinxiang Zhang,
- Hong Wu
Affiliations
- Jie Cheng
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Yan Huang
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Xiaohui Zhang
- Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University
- Yue Yu
- Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University
- Shumin Wu
- Department of Molecular and Medical Pharmacology, University of California, Los Angeles
- Jing Jiao
- Department of Molecular and Medical Pharmacology, University of California, Los Angeles
- Linh Tran
- Department of Molecular and Medical Pharmacology, University of California, Los Angeles
- Wanru Zhang
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Ran Liu
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Liuzhen Zhang
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Mei Wang
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Mengyao Wang
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Wenyu Yan
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Yilin Wu
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- Fangtao Chi
- Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles
- Peng Jiang
- School of Life Sciences, Tsinghua University
- Xinxiang Zhang
- Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University
- Hong Wu
- The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing Advanced Innovation Center for Genomics, Peking University
- DOI
- https://doi.org/10.1038/s41467-020-15819-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
The PI3K/AKT signalling pathway regulates cancer metabolism. Here, the authors show a reciprocal positive feedback crosstalk between the PI3K/AKT and pentose phosphate pathway which promotes tumourigenesis.
