Nature Communications (Apr 2020)

TRIM21 and PHLDA3 negatively regulate the crosstalk between the PI3K/AKT pathway and PPP metabolism

  • Jie Cheng,
  • Yan Huang,
  • Xiaohui Zhang,
  • Yue Yu,
  • Shumin Wu,
  • Jing Jiao,
  • Linh Tran,
  • Wanru Zhang,
  • Ran Liu,
  • Liuzhen Zhang,
  • Mei Wang,
  • Mengyao Wang,
  • Wenyu Yan,
  • Yilin Wu,
  • Fangtao Chi,
  • Peng Jiang,
  • Xinxiang Zhang,
  • Hong Wu

DOI
https://doi.org/10.1038/s41467-020-15819-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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The PI3K/AKT signalling pathway regulates cancer metabolism. Here, the authors show a reciprocal positive feedback crosstalk between the PI3K/AKT and pentose phosphate pathway which promotes tumourigenesis.