The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Abstract

Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.

Keywords

• GPR35
• benserazide
• catechol
• pyrogallol