Frontiers in Aging Neuroscience (Nov 2020)

Propofol Requirement and EEG Alpha Band Power During General Anesthesia Provide Complementary Views on Preoperative Cognitive Decline

  • Cyril Touchard,
  • Jérôme Cartailler,
  • Jérôme Cartailler,
  • Charlotte Levé,
  • José Serrano,
  • David Sabbagh,
  • Elsa Manquat,
  • Jona Joachim,
  • Joaquim Mateo,
  • Etienne Gayat,
  • Etienne Gayat,
  • Denis Engemann,
  • Denis Engemann,
  • Fabrice Vallée,
  • Fabrice Vallée,
  • Fabrice Vallée

DOI
https://doi.org/10.3389/fnagi.2020.593320
Journal volume & issue
Vol. 12

Abstract

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Background: Although cognitive decline (CD) is associated with increased post-operative morbidity and mortality, routinely screening patients remains difficult. The main objective of this prospective study is to use the EEG response to a Propofol-based general anesthesia (GA) to reveal CD.Methods: 42 patients with collected EEG and Propofol target concentration infusion (TCI) during GA had a preoperative cognitive assessment using MoCA. We evaluated the performance of three variables to detect CD (MoCA < 25 points): age, Propofol requirement to induce unconsciousness (TCI at SEF95: 8–13 Hz) and the frontal alpha band power (AP at SEF95: 8–13 Hz).Results: The 17 patients (40%) with CD were significantly older (p < 0.001), had lower TCI (p < 0.001), and AP (p < 0.001). We found using logistic models that TCI and AP were the best set of variables associated with CD (AUC: 0.89) and performed better than age (p < 0.05). Propofol TCI had a greater impact on CD probability compared to AP, although both were complementary in detecting CD.Conclusion: TCI and AP contribute additively to reveal patient with preoperative cognitive decline. Further research on post-operative cognitive trajectory are necessary to confirm the interest of intra operative variables in addition or as a substitute to cognitive evaluation.

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