Protein Structure in Medicine - A Team-Based Learning Exercise

Abstract

Abstract This resource is an exercise designed specifically to be used in a team-based learning (TBL) format. The exercise covers protein structure, which is a basic topic of biochemistry and cell biology in medicine and dentistry. The exercise is presented here as a paper copy for ease of review for instructors. However, it can be presented to classes on a course server or as a PowerPoint presentation. The goals of the resource are to assess students' ability to recall facts and concepts concerning protein structure and to challenge students to apply and integrate the information they have learned in a TBL environment. The resource includes 10 individual readiness assurance test (IRAT)/group readiness assurance test (GRAT) multiple-choice questions that focus on concepts and facts of protein structure. The application in this resource raises questions concerning the structure and folding (or misfolding) of a variety of medically relevant proteins. The application is done one question at a time, with information from one question often being used by the next question. Questions relating to protein folding, sulfhydral bonds, chaperonins, insulin, and prion proteins are addressed. An instructor's guide to the TBL format and the IRAT/GRAT and application portions of the exercise is provided. This TBL exercise has been used for 4 years at the Indiana University School of Medicine–South Bend. The resource has been well received and evaluated by the students each year as an excellent TBL exercise that promoted their understanding and integration of facts and concepts of protein structure.

Keywords

• TBL
• Team-Based Learning
• Non-Covalent Interactions
• Amino Acid Structure
• Protein Purification
• Protein Folding