Frontiers in Aging Neuroscience (Jun 2021)
The Cerebellum Is Related to Cognitive Dysfunction in White Matter Hyperintensities
- Shanshan Cao,
- Shanshan Cao,
- Shanshan Cao,
- Jiajia Nie,
- Jiajia Nie,
- Jiajia Nie,
- Jun Zhang,
- Chen Chen,
- Chen Chen,
- Chen Chen,
- Xiaojing Wang,
- Xiaojing Wang,
- Yuanyuan Liu,
- Yuanyuan Liu,
- Yuting Mo,
- Yuting Mo,
- Yuting Mo,
- Baogen Du,
- Baogen Du,
- Baogen Du,
- Yajuan Hu,
- Yajuan Hu,
- Yajuan Hu,
- Yanghua Tian,
- Yanghua Tian,
- Yanghua Tian,
- Yanghua Tian,
- Qiang Wei,
- Qiang Wei,
- Qiang Wei,
- Kai Wang,
- Kai Wang,
- Kai Wang,
- Kai Wang
Affiliations
- Shanshan Cao
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Shanshan Cao
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Shanshan Cao
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Jiajia Nie
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Jiajia Nie
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Jiajia Nie
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Jun Zhang
- Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China
- Chen Chen
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Chen Chen
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Chen Chen
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Xiaojing Wang
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Xiaojing Wang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Yuanyuan Liu
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Yuanyuan Liu
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Yuting Mo
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Yuting Mo
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Yuting Mo
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Baogen Du
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Baogen Du
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Baogen Du
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Yajuan Hu
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Yajuan Hu
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Yajuan Hu
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Yanghua Tian
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Yanghua Tian
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Yanghua Tian
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Yanghua Tian
- Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China
- Qiang Wei
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Qiang Wei
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Qiang Wei
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Kai Wang
- The School of Mental Health and Psychological Sciences, Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, China
- Kai Wang
- Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, China
- Kai Wang
- Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, China
- Kai Wang
- Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, China
- DOI
- https://doi.org/10.3389/fnagi.2021.670463
- Journal volume & issue
-
Vol. 13
Abstract
ObjectiveWhite matter hyperintensities (WMHs) on magnetic resonance imaging (MRI) is frequently presumed to be secondary to cerebral small vessel disease (CSVD) and associated with cognitive decline. The cerebellum plays a key role in cognition and has dense connections with other brain regions. Thus, the aim of this study was to investigate if cerebellar abnormalities could occur in CSVD patients with WMHs and the possible association with cognitive performances.MethodsA total of 104 right-handed patients with WMHs were divided into the mild WMHs group (n = 39), moderate WMHs group (n = 37), and severe WMHs group (n = 28) according to the Fazekas scale, and 36 healthy controls were matched for sex ratio, age, education years, and acquired resting-state functional MRI. Analysis of voxel-based morphometry of gray matter volume (GMV) and seed-to-whole-brain functional connectivity (FC) was performed from the perspective of the cerebellum, and their correlations with neuropsychological variables were explored.ResultsThe analysis revealed a lower GMV in the bilateral cerebellum lobule VI and decreased FC between the left- and right-sided cerebellar lobule VI with the left anterior cingulate gyri in CSVD patients with WMHs. Both changes in structure and function were correlated with cognitive impairment in patients with WMHs.ConclusionOur study revealed damaged GMV and FC in the cerebellum associated with cognitive impairment. This indicates that the cerebellum may play a key role in the modulation of cognitive function in CSVD patients with WMHs.
Keywords
- cerebellum
- white matter hyperintensities
- resting-state functional connectivity
- voxel-based morphometry
- magnetic resonance imaging
