Nature Communications (May 2021)

The role of maternal preconception vitamin D status in human offspring sex ratio

  • Alexandra C. Purdue-Smithe,
  • Keewan Kim,
  • Carrie Nobles,
  • Enrique F. Schisterman,
  • Karen C. Schliep,
  • Neil J. Perkins,
  • Lindsey A. Sjaarda,
  • Joshua R. Freeman,
  • Sonia L. Robinson,
  • Jeannie G. Radoc,
  • James L. Mills,
  • Robert M. Silver,
  • Aijun Ye,
  • Sunni L. Mumford

DOI
https://doi.org/10.1038/s41467-021-23083-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Higher vitamin D is associated with improved pregnancy and live birth rates, but its potential role in the human offspring sex ratio in unknown. Here, the authors show that the levels of vitamin D at preconception are positively associated with male live birth, particularly among women presenting inflammatory markers.