Nature Communications (Mar 2021)
Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
Abstract
Mitochondrial content in extracellular vesicles (EVs) can enhance inflammation, although its role in noninflammatory conditions is unclear. Here, the authors show that mitochondria-derived vesicles target material to EVs, whereas Parkin directs damaged mitochondrial content to lysosomes, providing insight into mitochondria-driven immune responses.