Discovery of a Novel Non-Narcotic Analgesic Derived from the CL-20 Explosive: Synthesis, Pharmacology, and Target Identification of Thiowurtzine, a Potent Inhibitor of the Opioid Receptors and the Ion Channels

• Stephanie Aguero,
• Simon Megy,
• Valeria V. Eremina,
• Alexander I. Kalashnikov,
• Svetlana G. Krylova,
• Daria A. Kulagina,
• Ksenia A. Lopatina,
• Mailys Fournier,
• Tatyana N. Povetyeva,
• Alexander B. Vorozhtsov,
• Sergey V. Sysolyatin,
• Vadim V. Zhdanov,
• Raphael Terreux

Affiliations

Stephanie Aguero

Équipe ECMO, Laboratoire de Biologie Tissulaire et d’Ingénierie (LBTI), UMR5305, Université Lyon 1, Lyon, France

Simon Megy

Équipe ECMO, Laboratoire de Biologie Tissulaire et d’Ingénierie (LBTI), UMR5305, Université Lyon 1, Lyon, France

Valeria V. Eremina

Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), Biysk, Altai Krai, Russia

Alexander I. Kalashnikov

Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), Biysk, Altai Krai, Russia

Svetlana G. Krylova

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia

Daria A. Kulagina

Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), Biysk, Altai Krai, Russia

Ksenia A. Lopatina

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia

Mailys Fournier

Équipe ECMO, Laboratoire de Biologie Tissulaire et d’Ingénierie (LBTI), UMR5305, Université Lyon 1, Lyon, France

Tatyana N. Povetyeva

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia

Alexander B. Vorozhtsov

National Research Tomsk State University, Tomsk, Russia

Sergey V. Sysolyatin

Institute for Problems of Chemical and Energetic Technologies, Siberian Branch of the Russian Academy of Sciences (IPCET SB RAS), Biysk, Altai Krai, Russia

Vadim V. Zhdanov

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russia

Raphael Terreux

Équipe ECMO, Laboratoire de Biologie Tissulaire et d’Ingénierie (LBTI), UMR5305, Université Lyon 1, Lyon, France