Sub-nanowatt resolution direct calorimetry for probing real-time metabolic activity of individual C. elegans worms

Sunghoon Hur; Rohith Mittapally; Swathi Yadlapalli; Pramod Reddy; Edgar Meyhofer

doi:10.1038/s41467-020-16690-y

Nature Communications (Jun 2020)

Sub-nanowatt resolution direct calorimetry for probing real-time metabolic activity of individual C. elegans worms

Sunghoon Hur,
Rohith Mittapally,
Swathi Yadlapalli,
Pramod Reddy,
Edgar Meyhofer

Affiliations

Sunghoon Hur: Department of Mechanical Engineering, University of Michigan
Rohith Mittapally: Department of Mechanical Engineering, University of Michigan
Swathi Yadlapalli: Department of Cell and Developmental Biology, University of Michigan
Pramod Reddy: Department of Mechanical Engineering, University of Michigan
Edgar Meyhofer: Department of Mechanical Engineering, University of Michigan

DOI: https://doi.org/10.1038/s41467-020-16690-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 9

Abstract

Read online

Calorimetry is widely used for metabolic studies, but measurements of single cells and small organisms are limited by the sensitivity of current techniques. Here the authors develop a sensitive platform for performing time-resolved metabolic measurements of single C. elegans worms from larval to adult stages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal