Communications Biology (Mar 2021)
Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer
- Ling Cai,
- Hongyu Liu,
- Fang Huang,
- Junya Fujimoto,
- Luc Girard,
- Jun Chen,
- Yongwen Li,
- Yu-An Zhang,
- Dhruba Deb,
- Victor Stastny,
- Karine Pozo,
- Christin S. Kuo,
- Gaoxiang Jia,
- Chendong Yang,
- Wei Zou,
- Adeeb Alomar,
- Kenneth Huffman,
- Mahboubeh Papari-Zareei,
- Lin Yang,
- Benjamin Drapkin,
- Esra A. Akbay,
- David S. Shames,
- Ignacio I. Wistuba,
- Tao Wang,
- Jane E. Johnson,
- Guanghua Xiao,
- Ralph J. DeBerardinis,
- John D. Minna,
- Yang Xie,
- Adi F. Gazdar
Affiliations
- Ling Cai
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center
- Hongyu Liu
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center
- Fang Huang
- Children’s Research Institute, UT Southwestern Medical Center
- Junya Fujimoto
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center
- Luc Girard
- Simmons Comprehensive Cancer Center, UT Southwestern Medical Center
- Jun Chen
- Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital
- Yongwen Li
- Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital
- Yu-An Zhang
- Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center
- Dhruba Deb
- Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center
- Victor Stastny
- Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center
- Karine Pozo
- Department of Internal Medicine, UT Southwestern Medical Center
- Christin S. Kuo
- Department of Pediatrics, Stanford University
- Gaoxiang Jia
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center
- Chendong Yang
- Children’s Research Institute, UT Southwestern Medical Center
- Wei Zou
- Department of Oncology Biomarker Development, Genentech Inc.
- Adeeb Alomar
- Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center
- Kenneth Huffman
- Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center
- Mahboubeh Papari-Zareei
- Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center
- Lin Yang
- Department of Pathology, National Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Benjamin Drapkin
- Simmons Comprehensive Cancer Center, UT Southwestern Medical Center
- Esra A. Akbay
- Department of Pathology, UT Southwestern Medical Center
- David S. Shames
- Department of Oncology Biomarker Development, Genentech Inc.
- Ignacio I. Wistuba
- Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center
- Tao Wang
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center
- Jane E. Johnson
- Simmons Comprehensive Cancer Center, UT Southwestern Medical Center
- Guanghua Xiao
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center
- Ralph J. DeBerardinis
- Children’s Research Institute, UT Southwestern Medical Center
- John D. Minna
- Simmons Comprehensive Cancer Center, UT Southwestern Medical Center
- Yang Xie
- Quantitative Biomedical Research Center, Department of Population and Data Sciences, UT Southwestern Medical Center
- Adi F. Gazdar
- Simmons Comprehensive Cancer Center, UT Southwestern Medical Center
- DOI
- https://doi.org/10.1038/s42003-021-01842-7
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Ling Cai et al. used transcriptomic profiling data of healthy lung, patient-derived small cell lung cancer cell lines, xenografts, and primary tumors to examine a link between neuroendocrine (NE) signatures and immune gene expression. Their findings suggest that cell-autonomous immune gene repression is a shared feature between healthy and tumor cells of NE lineage and may influence tumor-immune cell interaction and response to immunotherapy.
