Nature Communications (Jan 2021)
Sarcoma classification by DNA methylation profiling
- Christian Koelsche,
- Daniel Schrimpf,
- Damian Stichel,
- Martin Sill,
- Felix Sahm,
- David E. Reuss,
- Mirjam Blattner,
- Barbara Worst,
- Christoph E. Heilig,
- Katja Beck,
- Peter Horak,
- Simon Kreutzfeldt,
- Elke Paff,
- Sebastian Stark,
- Pascal Johann,
- Florian Selt,
- Jonas Ecker,
- Dominik Sturm,
- Kristian W. Pajtler,
- Annekathrin Reinhardt,
- Annika K. Wefers,
- Philipp Sievers,
- Azadeh Ebrahimi,
- Abigail Suwala,
- Francisco Fernández-Klett,
- Belén Casalini,
- Andrey Korshunov,
- Volker Hovestadt,
- Felix K. F. Kommoss,
- Mark Kriegsmann,
- Matthias Schick,
- Melanie Bewerunge-Hudler,
- Till Milde,
- Olaf Witt,
- Andreas E. Kulozik,
- Marcel Kool,
- Laura Romero-Pérez,
- Thomas G. P. Grünewald,
- Thomas Kirchner,
- Wolfgang Wick,
- Michael Platten,
- Andreas Unterberg,
- Matthias Uhl,
- Amir Abdollahi,
- Jürgen Debus,
- Burkhard Lehner,
- Christian Thomas,
- Martin Hasselblatt,
- Werner Paulus,
- Christian Hartmann,
- Ori Staszewski,
- Marco Prinz,
- Jürgen Hench,
- Stephan Frank,
- Yvonne M. H. Versleijen-Jonkers,
- Marije E. Weidema,
- Thomas Mentzel,
- Klaus Griewank,
- Enrique de Álava,
- Juan Díaz Martín,
- Miguel A. Idoate Gastearena,
- Kenneth Tou-En Chang,
- Sharon Yin Yee Low,
- Adrian Cuevas-Bourdier,
- Michel Mittelbronn,
- Martin Mynarek,
- Stefan Rutkowski,
- Ulrich Schüller,
- Viktor F. Mautner,
- Jens Schittenhelm,
- Jonathan Serrano,
- Matija Snuderl,
- Reinhard Büttner,
- Thomas Klingebiel,
- Rolf Buslei,
- Manfred Gessler,
- Pieter Wesseling,
- Winand N. M. Dinjens,
- Sebastian Brandner,
- Zane Jaunmuktane,
- Iben Lyskjær,
- Peter Schirmacher,
- Albrecht Stenzinger,
- Benedikt Brors,
- Hanno Glimm,
- Christoph Heining,
- Oscar M. Tirado,
- Miguel Sáinz-Jaspeado,
- Jaume Mora,
- Javier Alonso,
- Xavier Garcia del Muro,
- Sebastian Moran,
- Manel Esteller,
- Jamal K. Benhamida,
- Marc Ladanyi,
- Eva Wardelmann,
- Cristina Antonescu,
- Adrienne Flanagan,
- Uta Dirksen,
- Peter Hohenberger,
- Daniel Baumhoer,
- Wolfgang Hartmann,
- Christian Vokuhl,
- Uta Flucke,
- Iver Petersen,
- Gunhild Mechtersheimer,
- David Capper,
- David T. W. Jones,
- Stefan Fröhling,
- Stefan M. Pfister,
- Andreas von Deimling
Affiliations
- Christian Koelsche
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Daniel Schrimpf
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Damian Stichel
- Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Martin Sill
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Felix Sahm
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- David E. Reuss
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Mirjam Blattner
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Barbara Worst
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Christoph E. Heilig
- Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)
- Katja Beck
- Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)
- Peter Horak
- Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)
- Simon Kreutzfeldt
- Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)
- Elke Paff
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Sebastian Stark
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Pascal Johann
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Florian Selt
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Jonas Ecker
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Dominik Sturm
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Kristian W. Pajtler
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Annekathrin Reinhardt
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Annika K. Wefers
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Philipp Sievers
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Azadeh Ebrahimi
- Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Abigail Suwala
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Francisco Fernández-Klett
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Belén Casalini
- Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Andrey Korshunov
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- Volker Hovestadt
- Broad Institute of MIT and Harvard
- Felix K. F. Kommoss
- Department of General Pathology, Institute of Pathology, Heidelberg University Hospital
- Mark Kriegsmann
- Department of General Pathology, Institute of Pathology, Heidelberg University Hospital
- Matthias Schick
- Genomics and Proteomics Core Facility, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Melanie Bewerunge-Hudler
- Genomics and Proteomics Core Facility, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Till Milde
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Olaf Witt
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Andreas E. Kulozik
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Marcel Kool
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Laura Romero-Pérez
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Thomas G. P. Grünewald
- Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich
- Thomas Kirchner
- Institute of Pathology, Faculty of Medicine, LMU Munich
- Wolfgang Wick
- Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg
- Michael Platten
- Department of Neurology, Mannheim University Medical Center, University of Heidelberg
- Andreas Unterberg
- Department of Neurosurgery, Heidelberg University Hospital
- Matthias Uhl
- Department of Radiation Oncology, Heidelberg University Hospital
- Amir Abdollahi
- Department of Radiation Oncology, Heidelberg University Hospital
- Jürgen Debus
- Department of Radiation Oncology, Heidelberg University Hospital
- Burkhard Lehner
- Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital
- Christian Thomas
- Institute of Neuropathology, University Hospital Münster
- Martin Hasselblatt
- Institute of Neuropathology, University Hospital Münster
- Werner Paulus
- Institute of Neuropathology, University Hospital Münster
- Christian Hartmann
- Department of Neuropathology, Institute of Pathology, Hannover Medical School (MHH)
- Ori Staszewski
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Marco Prinz
- Institute of Neuropathology, Faculty of Medicine, University of Freiburg
- Jürgen Hench
- Department of Neuropathology, Institute of Pathology, Basel University Hospital
- Stephan Frank
- Department of Neuropathology, Institute of Pathology, Basel University Hospital
- Yvonne M. H. Versleijen-Jonkers
- Department of Medical Oncology, Radboud University Medical Center
- Marije E. Weidema
- Department of Medical Oncology, Radboud University Medical Center
- Thomas Mentzel
- Dermatopathology Bodensee
- Klaus Griewank
- Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen
- Enrique de Álava
- Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital, CSIC/University of Sevilla/CIBERONC
- Juan Díaz Martín
- Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital, CSIC/University of Sevilla/CIBERONC
- Miguel A. Idoate Gastearena
- Department of Pathological Anatomy, Clínica Universidad de Navarra, University of Navarra
- Kenneth Tou-En Chang
- Department of Pathology and Laboratory Medicine, KK Women’s and Children’s Hospital
- Sharon Yin Yee Low
- Department of Neurosurgery, National Neuroscience Institute
- Adrian Cuevas-Bourdier
- National Center of Pathology (NCP), Laboratoire National de Santé (LNS)
- Michel Mittelbronn
- National Center of Pathology (NCP), Laboratoire National de Santé (LNS)
- Martin Mynarek
- Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
- Stefan Rutkowski
- Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
- Ulrich Schüller
- Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
- Viktor F. Mautner
- Department of Neurology, University Medical Center Hamburg-Eppendorf
- Jens Schittenhelm
- Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tübingen
- Jonathan Serrano
- Department of Pathology, New York University School of Medicine
- Matija Snuderl
- Department of Pathology, New York University School of Medicine
- Reinhard Büttner
- Institute of Pathology, Cologne University Hospital
- Thomas Klingebiel
- Department of Pediatric Hematology and Oncology, University Children’s Hospital
- Rolf Buslei
- Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald
- Manfred Gessler
- Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Würzburg University
- Pieter Wesseling
- Princess Máxima Center for Pediatric Oncology
- Winand N. M. Dinjens
- Department of Pathology, Erasmus MC Cancer Institute
- Sebastian Brandner
- Department of Neurodegeneration, Institute of Neurology, University College London
- Zane Jaunmuktane
- Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust
- Iben Lyskjær
- Research Department of Pathology, University College London
- Peter Schirmacher
- Department of General Pathology, Institute of Pathology, Heidelberg University Hospital
- Albrecht Stenzinger
- Department of General Pathology, Institute of Pathology, Heidelberg University Hospital
- Benedikt Brors
- Division of Applied Bioinformatics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ)
- Hanno Glimm
- Translational and Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ)
- Christoph Heining
- Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ)
- Oscar M. Tirado
- Sarcoma Research Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), CIBERONC
- Miguel Sáinz-Jaspeado
- Sarcoma Research Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), CIBERONC
- Jaume Mora
- Department of Pediatric Onco-Hematology and Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu
- Javier Alonso
- Pediatric Solid Tumor Laboratory, Human Genetic Department, Research Institute of Rare Diseases, Instituto de Salud Carlos III (ISCIII)
- Xavier Garcia del Muro
- Medical Oncology Service, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona
- Sebastian Moran
- Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL)
- Manel Esteller
- Josep Carreras Leukaemia Research Institute (IJC), Badalona
- Jamal K. Benhamida
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Marc Ladanyi
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Eva Wardelmann
- Gerhard Domagk Institute of Pathology, University Hospital Münster
- Cristina Antonescu
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Adrienne Flanagan
- Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust
- Uta Dirksen
- Pediatrics III Pediatric Hematology, Oncology, Immunology, Cardiology, Pulmonology, West German Cancer Center, University Hospital Essen
- Peter Hohenberger
- Division of Surgical Oncology and Thoracic Surgery, Mannheim University Medical Center, University of Heidelberg
- Daniel Baumhoer
- Bone Tumour Reference Centre at the Institute of Pathology, University Hospital Basel and University of Basel
- Wolfgang Hartmann
- Division of Translational Pathology, Gerhard Domagk Institute of Pathology, University Hospital Münster
- Christian Vokuhl
- Department of Pediatric Pathology, University Hospital of Schleswig-Holstein
- Uta Flucke
- Department of Pathology, Radboud University Medical Center
- Iver Petersen
- Institute of Pathology, SRH Poliklinik Gera GmbH
- Gunhild Mechtersheimer
- Department of General Pathology, Institute of Pathology, Heidelberg University Hospital
- David Capper
- Department of Neuropathology, Charité Universitätsmedizin Berlin
- David T. W. Jones
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Stefan Fröhling
- Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK)
- Stefan M. Pfister
- Hopp Children’s Cancer Center Heidelberg (KiTZ)
- Andreas von Deimling
- Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital
- DOI
- https://doi.org/10.1038/s41467-020-20603-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 10
Abstract
Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.
