Microcystic/reticular schwannoma of the adrenal gland: a case report and literature review

Abstract

Microcystic/reticular schwannoma is a recently described, rare, distinctive histological variant of schwannoma with a predilection for the gastrointestinal tract [1]. Unlike classic Schwannoma, most microcystic/reticular Schwannoma had an incomplete fibrous capsule, two distinctly different areas - hypercellular areas and myxoid areas, Microcystic/reticular schwannoma occurs in the internal organs, especially in the digestive tract and a rare case occurs in the adrenal glands [1–3]. Herein, we report a case of microcystic/reticular schwannoma of the adrenal gland, in a 60-year-old male with 7.0 cm × 6.0 cm × 5 cm mass in the left adrenal gland. The tumor showed a vague multinodular appearance with a pushing border and arranged in a microcystic and reticular growth pattern with anastomosing and intersecting strands of spindle cells in a myxoid or collagenous/hyalinized stroma. Tumor cells showed diffuse nuclear and cytoplasmic positivity for S-100. Keywords: Microcystic/reticular schwannonma, Adrenal gland, Pathological features, Differential diagnosis