EZH2: Its regulation and roles in immune disturbance of SLE

Yiying Yang; Yiying Yang; Yiying Yang; Ke Liu; Ke Liu; Meidong Liu; Meidong Liu; Huali Zhang; Huali Zhang; Huali Zhang; Muyao Guo; Muyao Guo; Muyao Guo

doi:10.3389/fphar.2022.1002741

Frontiers in Pharmacology (Oct 2022)

EZH2: Its regulation and roles in immune disturbance of SLE

Yiying Yang,
Yiying Yang,
Yiying Yang,
Ke Liu,
Ke Liu,
Meidong Liu,
Meidong Liu,
Huali Zhang,
Huali Zhang,
Huali Zhang,
Muyao Guo,
Muyao Guo,
Muyao Guo

Affiliations

Yiying Yang: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China
Yiying Yang: Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, China
Yiying Yang: Sepsis Translational Medicine Key Lab of Hunan Province, China
Ke Liu: Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, China
Ke Liu: Sepsis Translational Medicine Key Lab of Hunan Province, China
Meidong Liu: Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, China
Meidong Liu: Sepsis Translational Medicine Key Lab of Hunan Province, China
Huali Zhang: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China
Huali Zhang: Department of Pathophysiology, School of Basic Medicine Science, Central South University, Changsha, China
Huali Zhang: Sepsis Translational Medicine Key Lab of Hunan Province, China
Muyao Guo: Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, China
Muyao Guo: Provincial Clinical Research Center for Rheumatic and Immunologic Diseases, Xiangya Hospital, Changsha, China
Muyao Guo: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China

DOI: https://doi.org/10.3389/fphar.2022.1002741
Journal volume & issue: Vol. 13

Abstract

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The pathogenesis of systemic lupus erythematosus (SLE) is related to immune homeostasis imbalance. Epigenetic mechanisms have played a significant role in breaking immune tolerance. Enhancer of zeste homolog 2 (EZH2), the specific methylation transferase of lysine at position 27 of histone 3, is currently found to participate in the pathogenesis of SLE through affecting multiple components of the immune system. This review mainly expounds the mechanisms underlying EZH2-mediated disruption of immune homeostasis in SLE patients, hoping to provide new ideas in the pathogenesis of SLE and new targets for future treatment.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

About the journal

Abstract

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