Frontiers in Public Health (Mar 2022)
Gut Bacteria Erysipelatoclostridium and Its Related Metabolite Ptilosteroid A Could Predict Radiation-Induced Intestinal Injury
- Shang Cai,
- Shang Cai,
- Shang Cai,
- Yongqiang Yang,
- Yongqiang Yang,
- Yongqiang Yang,
- Yuehong Kong,
- Yuehong Kong,
- Yuehong Kong,
- Qi Guo,
- Qi Guo,
- Qi Guo,
- Yingying Xu,
- Yingying Xu,
- Yingying Xu,
- Pengfei Xing,
- Pengfei Xing,
- Pengfei Xing,
- Yanze Sun,
- Yanze Sun,
- Yanze Sun,
- Jianjun Qian,
- Jianjun Qian,
- Jianjun Qian,
- Ruizhe Xu,
- Ruizhe Xu,
- Ruizhe Xu,
- Liwei Xie,
- Liwei Xie,
- Liwei Xie,
- Yijia Hu,
- Yijia Hu,
- Yijia Hu,
- Min Wang,
- Ming Li,
- Ye Tian,
- Ye Tian,
- Ye Tian,
- Weidong Mao,
- Weidong Mao,
- Weidong Mao
Affiliations
- Shang Cai
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Shang Cai
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Shang Cai
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Yongqiang Yang
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Yongqiang Yang
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Yongqiang Yang
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Yuehong Kong
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Yuehong Kong
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Yuehong Kong
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Qi Guo
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Qi Guo
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Qi Guo
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Yingying Xu
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Yingying Xu
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Yingying Xu
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Pengfei Xing
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Pengfei Xing
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Pengfei Xing
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Yanze Sun
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Yanze Sun
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Yanze Sun
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Jianjun Qian
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Jianjun Qian
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Jianjun Qian
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Ruizhe Xu
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Ruizhe Xu
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Ruizhe Xu
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Liwei Xie
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Liwei Xie
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Liwei Xie
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Yijia Hu
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Yijia Hu
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Yijia Hu
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Min Wang
- Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Ming Li
- State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Medical College of Soochow University, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China
- Ye Tian
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Ye Tian
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Ye Tian
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- Weidong Mao
- Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China
- Weidong Mao
- Institute of Radiotherapy and Oncology, Soochow University, Suzhou, China
- Weidong Mao
- Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
- DOI
- https://doi.org/10.3389/fpubh.2022.862598
- Journal volume & issue
-
Vol. 10
Abstract
It is difficult to study the intestinal damage induced by space radiation to astronauts directly, and few prediction models exist. However, we can simulate it in patients with pelvic tumor radiotherapy (RT). Radiation-induced intestinal injury (RIII) is common in cancer patients who receieved pelvic and abdominal RT. We dynamically analyzed gut microbiota and metabolites alterations in 17 cervical and endometrial cancer patients after pelvic RT. In patients who later developed grade 2 RIII, dysbiosis of gut microbiota and metabolites were observed. Univariate analysis showed that Erysipelatoclostridium and ptilosteroid A were related to the occurrence of grade 2 RIII. Notably, a strong positive correlation between gut bacteria Erysipelatoclostridium relative abundance and gut metabolite ptilosteroid A expression was found. Furthermore, combinations of Erysipelatoclostridium and ptilosteroid A could provide good diagnostic markers for grade 2 RIII. In conclusion, gut bacteria Erysipelatoclostridium and its related metabolite ptilosteroid A may collaboratively predict RIII, and could be diagnostic biomarkers for RIII and space radiation injury.
Keywords
- radiation-induced intestinal injury
- biomarker
- gut bacteria
- gut bacteria related metabolite
- radiotherapy
