Nature Communications (Dec 2017)

IRF8-dependent molecular complexes control the Th9 transcriptional program

  • Etienne Humblin,
  • Marion Thibaudin,
  • Fanny Chalmin,
  • Valentin Derangère,
  • Emeric Limagne,
  • Corentin Richard,
  • Richard A. Flavell,
  • Sandy Chevrier,
  • Sylvain Ladoire,
  • Hélène Berger,
  • Romain Boidot,
  • Lionel Apetoh,
  • Frédérique Végran,
  • François Ghiringhelli

DOI
https://doi.org/10.1038/s41467-017-01070-w
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

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Interferon regulatory factors IRF regulate lymphoid development, but the specific function of IRF8 in helper T-cell polarization is unclear. Here the authors show that IRF8 forms a complex with IRF4, PU.1 and BATF to modulate the Th9 transcription program and expression of IL-4 and IL-9.