Translational Neuroscience (Nov 2021)
Cryptotanshinone ameliorates CUS-induced depressive-like behaviors in mice
- Wang Kaixin,
- Zhai Qingling,
- Wang Sanwang,
- Li Qiongyu,
- Liu Jing,
- Meng Fantao,
- Wang Wentao,
- Zhang Jinjie,
- Wang Dan,
- Zhao Di,
- Liu Cuilan,
- Dai Juanjuan,
- Li Chen,
- Cui Minghu,
- Chen Jinbo
Affiliations
- Wang Kaixin
- Department of Neurology, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong, 256603, China
- Zhai Qingling
- Department of Neurology, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong, 256603, China
- Wang Sanwang
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Li Qiongyu
- Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Liu Jing
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Meng Fantao
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Wang Wentao
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Zhang Jinjie
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Wang Dan
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Zhao Di
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Liu Cuilan
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Dai Juanjuan
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Li Chen
- Medical Research Center, Binzhou Medical University Hospital, Binzhou, Shandong, China
- Cui Minghu
- Department of Psychology, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong, 256603, China
- Chen Jinbo
- Department of Neurology, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou, Shandong, 256603, China
- DOI
- https://doi.org/10.1515/tnsci-2020-0198
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 469 – 481
Abstract
Cryptotanshinone (CPT), a natural quinoid diterpene, isolated from Salvia miltiorrhiza, has shown various pharmacological properties. However, its effect on chronic unpredictable stress (CUS)-induced depression phenotypes and the underlying mechanism remain unclear. Therefore, the aim of this study was to investigate whether CPT could exert an antidepressant effect.
Keywords
