OncoTargets and Therapy (Sep 2022)

Long-Term Treatment-Free Survival After Multimodal Therapy in a Patient with Stage IV Lung Adenocarcinoma

  • Takaoka H,
  • Terai H,
  • Emoto K,
  • Shigematsu L,
  • Ito F,
  • Saito A,
  • Okada M,
  • Ohgino K,
  • Ikemura S,
  • Yasuda H,
  • Nakachi I,
  • Kawada I,
  • Fukunaga K,
  • Soejima K

Journal volume & issue
Vol. Volume 15
pp. 981 – 989

Abstract

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Hatsuyo Takaoka,1 Hideki Terai,1 Katsura Emoto,2 Lisa Shigematsu,1 Fumimaro Ito,1 Ayaka Saito,1 Masahiko Okada,1 Keiko Ohgino,1 Shinnosuke Ikemura,3 Hiroyuki Yasuda,1 Ichiro Nakachi,4 Ichiro Kawada,1 Koichi Fukunaga,1 Kenzo Soejima3 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Pathology, Keio University School of Medicine, Tokyo, Japan; 3Department of Respiratory Medicine, Yamanashi University School of Medicine, Yamanashi, Japan; 4Pulmonary Division, Department of Internal Medicine, Saiseikai Utsunomiya Hospital, Utsunomiya, JapanCorrespondence: Hideki Terai, Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo, 160-8582, Japan, Tel +81-3-3353-3474, Fax +81-3-3353-3475, Email [email protected]: We report the first case of a patient with non-small cell lung cancer (NSCLC) with malignant pleural effusion (MPE) who achieved disease- and treatment-free survival for nearly 10 years. A 50-year-old man was diagnosed with NSCLC with MPE and underwent chemotherapy and salvage thoracic surgery. The patient received chemotherapy with cisplatin, pemetrexed, and bevacizumab, and a partial response was achieved. After informed consent was obtained from the patient, right middle lobectomy was performed to achieve local tumor control. Postoperative adjuvant chemotherapy with pemetrexed and bevacizumab was discontinued after almost 1 year of chemotherapy due to side effects such as diarrhea and muscle weakness. The patient has survived without recurrence of lung cancer for more than 11 years after being diagnosed and nearly 10 years after discontinuing chemotherapy.Keywords: malignant pleural effusion, bevacizumab, pemetrexed, salvage surgery, cure

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