One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG

B. Siva  Kumar; Y. Haranadha Reddy; C. Radha Rani; G. Chnadra Sekhar Reddy

doi:10.1155/2011/906320

E-Journal of Chemistry (Jan 2011)

One-Pot Synthesis and Antimicrobial Activity of Novel α-Aminophosphonates Using TMG

B. Siva Kumar,
Y. Haranadha Reddy,
C. Radha Rani,
G. Chnadra Sekhar Reddy

Affiliations

B. Siva Kumar: Department of Chemistry, Vel Tech Engineering College, Avadi, Chennai-600 062, India
Y. Haranadha Reddy: Department of Chemistry, Sri Venakateswara University, Tirupati-517 502, India
C. Radha Rani: Department of Chemistry, Sri Venakateswara University, Tirupati-517 502, India
G. Chnadra Sekhar Reddy: Department of Chemistry, Sri Venakateswara University, Tirupati-517 502, India

DOI: https://doi.org/10.1155/2011/906320
Journal volume & issue: Vol. 8, no. S1
pp. S137 – S142

Abstract

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α-Aminophosphonates (4a-j) were synthesized in one-pot simultaneous reaction of 4-bromo-3-methyl benzenamine (1), dimethylphosphite (3) and different aromatic aldehydes (2a-j) by Kabachnik-Fields reaction in the presence of tetramethylguanidine (TMG) (10 mole%) as catalyst in toluene at reflux temperature afforded 4a-j in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.

Published in E-Journal of Chemistry

ISSN: 0973-4945 (Print); 2090-9810 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.hindawi.com/journals/jchem/

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