A genetic cell context-dependent role for ZEB1 in lung cancer

Ting Zhang; Lixia Guo; Chad J. Creighton; Qiang Lu; Don L. Gibbons; Eunhee S. Yi; Bo Deng; Julian R. Molina; Zhifu Sun; Ping Yang; Yanan Yang

doi:10.1038/ncomms12231

Nature Communications (Jul 2016)

A genetic cell context-dependent role for ZEB1 in lung cancer

Ting Zhang,
Lixia Guo,
Chad J. Creighton,
Qiang Lu,
Don L. Gibbons,
Eunhee S. Yi,
Bo Deng,
Julian R. Molina,
Zhifu Sun,
Ping Yang,
Yanan Yang

Affiliations

Ting Zhang: Division of Pulmonary and Critical Care Medicine, Thoracic Disease Research Unit, Cancer Center and College of Medicine, Mayo Clinic, 200 First Street SW, Stabile Building Room st8-08 Rochester, Minnesota 55905, USA
Lixia Guo: Division of Pulmonary and Critical Care Medicine, Thoracic Disease Research Unit, Cancer Center and College of Medicine, Mayo Clinic, 200 First Street SW, Stabile Building Room st8-08 Rochester, Minnesota 55905, USA
Chad J. Creighton: Dan Duncan Cancer Center, Baylor College of Medicine
Qiang Lu: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine
Don L. Gibbons: Department of Thoracic Head and Neck Medical Oncology, M.D. Anderson Cancer Center
Eunhee S. Yi: Department of Laboratory Medicine and Pathology, Mayo Clinic
Bo Deng: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine
Julian R. Molina: Division of Medical Oncology, Mayo Clinic
Zhifu Sun: Division of Biomedical Statistics and Informatics, Mayo Clinic
Ping Yang: Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine
Yanan Yang: Division of Pulmonary and Critical Care Medicine, Thoracic Disease Research Unit, Cancer Center and College of Medicine, Mayo Clinic, 200 First Street SW, Stabile Building Room st8-08 Rochester, Minnesota 55905, USA

DOI: https://doi.org/10.1038/ncomms12231
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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ZEB1 is a driver of epithelial-to-mesenchymal transition that usually promotes lung cancer in the context of KRAS mutation. Here, the authors uncover a growth suppressive role for ZEB1 in EGFRmutant lung adenocarcinoma, thus elucidating the context dependent function of this protein.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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