Covalently grafted human serum albumin coating mitigates the foreign body response against silicone implants in mice

Xianchi Zhou; Hongye Hao; Yifeng Chen; Wenzhong Cao; Zihao Zhu; Yanwen Ni; Zuolong Liu; Fan Jia; Youxiang Wang; Jian Ji; Peng Zhang

Bioactive Materials (Apr 2024)

Covalently grafted human serum albumin coating mitigates the foreign body response against silicone implants in mice

Xianchi Zhou,
Hongye Hao,
Yifeng Chen,
Wenzhong Cao,
Zihao Zhu,
Yanwen Ni,
Zuolong Liu,
Fan Jia,
Youxiang Wang,
Jian Ji,
Peng Zhang

Affiliations

Xianchi Zhou: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China
Hongye Hao: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China; International Research Center for X Polymers, International Campus, Zhejiang University, Haining, PR China
Yifeng Chen: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China; International Research Center for X Polymers, International Campus, Zhejiang University, Haining, PR China
Wenzhong Cao: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China
Zihao Zhu: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China
Yanwen Ni: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China
Zuolong Liu: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China
Fan Jia: Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, PR China
Youxiang Wang: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China; Corresponding author. MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China.
Jian Ji: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China; International Research Center for X Polymers, International Campus, Zhejiang University, Haining, PR China; State Key Laboratory of Transvascular Implantation Devices, Zhejiang University, Hangzhou, PR China; Corresponding author. MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China.
Peng Zhang: MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China; International Research Center for X Polymers, International Campus, Zhejiang University, Haining, PR China; State Key Laboratory of Transvascular Implantation Devices, Zhejiang University, Hangzhou, PR China; Corresponding author. MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, PR China.

Journal volume & issue: Vol. 34
pp. 482 – 493

Abstract

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Implantable biomaterials and biosensors are integral components of modern medical systems but often encounter hindrances due to the foreign body response (FBR). Herein, we report an albumin coating strategy aimed at addressing this challenge. Using a facile and scalable silane coupling strategy, human serum albumin (HSA) is covalently grafted to the surface of polydimethylsiloxane (PDMS) implants. This covalently grafted albumin coating remains stable and resistant to displacement by other proteins. Notably, the PDMS with covalently grafted HSA strongly resists the fibrotic capsule formation following a 180-day subcutaneous implantation in C57BL/6 mice. Furthermore, the albumin coating led to reduced recruitment of macrophages and triggered a mild immune activation pattern. Exploration of albumin coatings sourced from various mammalian species has shown that only HSA exhibited a promising anti-FBR effect. The albumin coating method reported here holds the potential to improve and extend the function of silicone-based implants by mitigating the host responses to subcutaneously implanted biomaterials.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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