Correlation between the structure and biological activity of some coordination compounds of isatin Schiff bases

Abstract

The complexes of Co(ll), Ni(ll), Cu(ll) and Zn(ll) with isatin Schiff bases were synthetised and their structures established by using elemental analysis, as well as by measuring the molar conductivity, AA, FTIR, UV/VIS and 1H NMR and applying TG analysis.Isatin Schiff bases show different antimicrobial activity due to the different nature of the carbonyl and amino components as well as its substituent. The complexes have an enhanced activity compared to the ligands due to the transition metal involved in the coordination. It is also evident that the complexeshave different antimicrobial activity, which is related to the nature and typeof coordinated metal.

Keywords

• isatin
• Schiff base
• Co(ll)
• Ni(ll)
• Cu(ll)
• Zn(ll)
• Antimicrobial activity