Voltage gating of mechanosensitive PIEZO channels

Mirko Moroni; M. Rocio Servin-Vences; Raluca Fleischer; Oscar Sánchez-Carranza; Gary R. Lewin

doi:10.1038/s41467-018-03502-7

Nature Communications (Mar 2018)

Voltage gating of mechanosensitive PIEZO channels

Mirko Moroni,
M. Rocio Servin-Vences,
Raluca Fleischer,
Oscar Sánchez-Carranza,
Gary R. Lewin

Affiliations

Mirko Moroni: Department of Neuroscience, Max-Delbrück Center for Molecular Medicine
M. Rocio Servin-Vences: Department of Neuroscience, Max-Delbrück Center for Molecular Medicine
Raluca Fleischer: Department of Neuroscience, Max-Delbrück Center for Molecular Medicine
Oscar Sánchez-Carranza: Department of Neuroscience, Max-Delbrück Center for Molecular Medicine
Gary R. Lewin: Department of Neuroscience, Max-Delbrück Center for Molecular Medicine

DOI: https://doi.org/10.1038/s41467-018-03502-7
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

Read online

PIEZO proteins form mechanosensitive ion channels. Here the authors present electrophysiological measurements that show that PIEZO channels are also modulated by voltage and can switch to a purely voltage gated mode, which is an evolutionary conserved property of this channel family.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal