C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

Baharan Fekry; Kristen A. Jeffries; Amin Esmaeilniakooshkghazi; Zdzislaw M. Szulc; Kevin J. Knagge; David R. Kirchner; David A. Horita; Sergey A. Krupenko; Natalia I. Krupenko

doi:10.1038/s41467-018-06650-y

Nature Communications (Oct 2018)

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

Baharan Fekry,
Kristen A. Jeffries,
Amin Esmaeilniakooshkghazi,
Zdzislaw M. Szulc,
Kevin J. Knagge,
David R. Kirchner,
David A. Horita,
Sergey A. Krupenko,
Natalia I. Krupenko

Affiliations

Baharan Fekry: University of North Carolina at Chapel Hill Nutrition Research Institute
Kristen A. Jeffries: University of North Carolina at Chapel Hill Nutrition Research Institute
Amin Esmaeilniakooshkghazi: University of North Carolina at Chapel Hill Nutrition Research Institute
Zdzislaw M. Szulc: Department of Biochemistry and Molecular Biology, Medical University of South Carolina
Kevin J. Knagge: David Murdock Research Institute
David R. Kirchner: David Murdock Research Institute
David A. Horita: University of North Carolina at Chapel Hill Nutrition Research Institute
Sergey A. Krupenko: University of North Carolina at Chapel Hill Nutrition Research Institute
Natalia I. Krupenko: University of North Carolina at Chapel Hill Nutrition Research Institute

DOI: https://doi.org/10.1038/s41467-018-06650-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and activation of its downstream targets.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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