ASYMMETRIC DIMETHYLARGININE, THE PROMOTER FACTOR OF CARDIOVASCULAR PATHOLOGIES

Abstract

Amongst all the cardiovascular risk factors known until now, it has been recently discovered one that acts independently and has powerful proatherogenic properties. Its action leads to a quick endothelium damage through increased oxidative stress at this level . Asymmetric dimethylarginine, a metilated protein, is a new prognostic factor of cardiovascular pathologies and its importance started to appear lately, when studies performed on patients with renal failure contoured an increased mortality due to cardiovascular complications in these patients. The particular characteristic that makes it different than the other known risk factors is its capacity to directly compete against nitric oxide synthase, being the most powerful inhibitor, leading to a proatherogenic state.

Keywords

• asymmetric dimethylarginine
• endothelium dysfunction
• cardiovascular risk factors
• hypercholestrolaemia