Can Blood Biomarkers Be Used to Assess Oxidative Stress in COPD Patients After Pulmonary Rehabilitation

Abstract

Ayşegül Beykumül,1 Yuksel Ersoy,2 Gazi Gülbaş,3 Salim Neselioglu4 1Pulmonary Rehabilitation Unit, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey; 2Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Inonu University, Malatya, Turkey; 3Department of Chest Diseases, Faculty of Medicine, Inonu University, Malatya, Turkey; 4Department of Medical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, TurkeyCorrespondence: Ayşegül Beykumül, Pulmonary Rehabilitation Unit, Turgut Ozal Medical Center, Inonu University, Elazig Road 11th. Km. Battalgazi, Malatya, 44280, Turkey, Tel [phone], Fax [phone], Email [email protected]: To determine the level of oxidative stress in the body due to pulmonary rehabilitation (PR) with thiols and disulfide and to investigate their relationship with indirect markers such as creatine kinase (CK), creatine kinase – MB (CK-MB), and lactate dehydrogenase (LDH), which show cell destruction.Patients and Methods: Patients with chronic obstructive pulmonary disease (COPD) are included in inpatient and outpatient care. They were evaluated before and after for PR, and an exercise program was prescribed. In addition, native thiol (NT), total thiol (TT), disulfide (DS), LDH, CK, and CK-MB values were tested.Results: The mean age of 21 patients was 63± 7.31 years. Eleven of them were outpatients and 10 of them were inpatients. Most of the patients were male (M/F=20/1, 95.2/4.8%). There was a significant difference in pulmonary function tests (PFT), St. George Respiratory Questionnaire (SGRQ), and 1 repetition maximum (1RM) before and after the treatment (p< 0.001). There was a correlation between PFT and 1RM upper extremity. While there was no significant difference between thiols and disulfide, according to GOLD scores, there was a significant difference in patients with level 3-MMRC. No correlation was found between LDH, CK, CK-MB, and thiols, DS. ΔCK was found to be associated with ΔDS, and ΔCK-MB with ΔNT, and ΔTT.Conclusion: PR contributes to the antioxidant process by improving respiration and reducing oxidative stress. The decrease in LDH, CK with PR, increase in CK-MB, and correlation of CK with thiols and DS gave a different interpretation. In this case, it should be considered that oxidative stress may also be increased in people with high CK values.Keywords: CK, CK-MB, COPD, LDH, oxidative stress, pulmonary rehabilitation

Keywords

• ck
• ck-mb
• copd
• ldh
• oxidative stress
• pulmonary rehabilitation.