Spectrum of Orbito-ocular Tumour in India: Histopathological and Immunohistochemical Study

Abstract

Introduction: Orbito-ocular tumours are an important cause of morbidity and mortality. Their incidence is low but requires immediate diagnosis and treatment. There are limited research studies on histopathological and immunohistochemical studies of ocular tumour from India and these studies may provide valuable information and aid in accurate diagnosis and management. Aim: To elucidate distribution of age, sex, location of tumour, histopathological, immunohistochemical findings and any other relevant information with respect to orbito-ocular tumours. Materials and Methods: A retrospective observational analysis was conducted over a period of five years from March 2008 to February 2013, in the Department of Pathology in a tertiary care centre, Assam, India. Hospital records of 55 patients with malignant ocular tumours were collected, reviewed and statistically analysed. Results: In the present study, a total of 55 cases were included. Out of which, two cases were inconclusive due to inadequate material. Remaining, 53 cases included both intraocular and orbital malignant tumours. Tumours were found slightly more in males (34 cases) compared to females (19) with a ratio of 1.8 to 1. Squamous Cell Carcinoma (SCC) comprised the maximum number (16 cases) followed by Retinoblastoma (RB) in 15 cases and melanoma in 11 cases. In children most common malignancy was RB followed by rhadomyosarcoma (RMS). Conclusion: In this study it was found that SCC was the most common malignant tumour in adults whereas RB was the most common tumour in children.

Keywords

• : eye
• immunohistochemistry
• melanoma
• retinoblastoma
• squamous cell carcinoma