Acta Crystallographica Section E (Sep 2010)

N-(4-Methoxyphenyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea

  • Alan J. Lough,
  • Justin W. Hicks,
  • John F. Valliant,
  • Alan A. Wilson,
  • Neil Vasdev

DOI
https://doi.org/10.1107/S1600536810032186
Journal volume & issue
Vol. 66, no. 9
pp. o2339 – o2339

Abstract

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The title compound, C11H10N4O4S, is a derivative of N-(4-methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea (AR-A014418), a known glycogen synthase kinase 3β (GSK-3β) inhibitor. All non-H atoms in the molecule are essentially coplanar, with an r.m.s. deviation of 0.045 Å and a maximum deviation of 0.115 (2) Å for the carbonyl O atom. In the crystal structure, molecules are linked via N—H...O hydrogen bonds into one-dimensional chains along [101].