Avaliação do perfil de dissolução de medicamentos utilizando-se espectroscopia eletrônica multivariada

Abstract

In this work the evaluation of the dissolution profile of captopril-hydrochlorothiazide and zidovudine-lamivudine associations were carried out by multivariate spectroscopic method. The models were developed by partial least square regression from 20 synthetic mixtures using mean-centered spectral data. The external validation was accomplished with 5 synthetic mixtures shown mean prevision error of about 1%. Good agreement was observed in the analyses of commercial drugs (content uniformity and dissolution profile), considering the results obtained by the standard chromatographic method, with prevision error lower than 10%.

Keywords

• captopril-hydrochlorotiazide
• zidovudine-lamivudine
• multivariate spectroscopy