Structural basis of ion uptake in copper-transporting P1B-type ATPases

Nina Salustros; Christina Grønberg; Nisansala S. Abeyrathna; Pin Lyu; Fredrik Orädd; Kaituo Wang; Magnus Andersson; Gabriele Meloni; Pontus Gourdon

doi:10.1038/s41467-022-32751-w

Nature Communications (Aug 2022)

Structural basis of ion uptake in copper-transporting P1B-type ATPases

Nina Salustros,
Christina Grønberg,
Nisansala S. Abeyrathna,
Pin Lyu,
Fredrik Orädd,
Kaituo Wang,
Magnus Andersson,
Gabriele Meloni,
Pontus Gourdon

Affiliations

Nina Salustros: Department of Biomedical Sciences, Copenhagen University
Christina Grønberg: Department of Biomedical Sciences, Copenhagen University
Nisansala S. Abeyrathna: Department of Chemistry and Biochemistry, The University of Texas at Dallas
Pin Lyu: Department of Biomedical Sciences, Copenhagen University
Fredrik Orädd: Department of Chemistry, Umeå University
Kaituo Wang: Department of Biomedical Sciences, Copenhagen University
Magnus Andersson: Department of Chemistry, Umeå University
Gabriele Meloni: Department of Chemistry and Biochemistry, The University of Texas at Dallas
Pontus Gourdon: Department of Biomedical Sciences, Copenhagen University

DOI: https://doi.org/10.1038/s41467-022-32751-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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P1B-type ATPases export excess transition metals from cells. Here, the authors report a molecular structure of CopA, a coppertransporting P1B-ATPase from A. fulgidus, in an inward-facing E1 conformation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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