An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

Michael B. Keough; James A. Rogers; Ping Zhang; Samuel K. Jensen; Erin L. Stephenson; Tieyu Chen; Mitchel G. Hurlbert; Lorraine W. Lau; Khalil S. Rawji; Jason R. Plemel; Marcus Koch; Chang-Chun Ling; V. Wee Yong

doi:10.1038/ncomms11312

Nature Communications (Apr 2016)

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

Michael B. Keough,
James A. Rogers,
Ping Zhang,
Samuel K. Jensen,
Erin L. Stephenson,
Tieyu Chen,
Mitchel G. Hurlbert,
Lorraine W. Lau,
Khalil S. Rawji,
Jason R. Plemel,
Marcus Koch,
Chang-Chun Ling,
V. Wee Yong

Affiliations

Michael B. Keough: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
James A. Rogers: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Ping Zhang: Department of Chemistry, University of Calgary
Samuel K. Jensen: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Erin L. Stephenson: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Tieyu Chen: Department of Chemistry, University of Calgary
Mitchel G. Hurlbert: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Lorraine W. Lau: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Khalil S. Rawji: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Jason R. Plemel: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Marcus Koch: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary
Chang-Chun Ling: Department of Chemistry, University of Calgary
V. Wee Yong: Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary

DOI: https://doi.org/10.1038/ncomms11312
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate remyelination in mice following focal demyelination.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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