1181 GEN1042-mIgG2a, an Fc-inert mouse-human chimeric variant of GEN1042 (DuoBody®-CD40x4–1BB), exhibits in vivo antitumor activity and peripheral immune modulation

• Karsten Pilones,
• Maria Jure-Kunkel,
• Homer Adams,
• Alexander Muik,
• Tahamtan Ahmadi,
• Ugur Sahin,
• Oezlem Tuereci,
• Kristina Nuermberger,
• Angelica Sette,
• Monique Luijten,
• Maren Köhne,
• Jasja Wolthoorn,
• Sina Fellermeier-Kopf

Affiliations

Karsten Pilones

Aff2 grid.137628.90000000121698901NYU School of Medicine New York NY USA

Maria Jure-Kunkel

12Genmab, Princeton, USA

Homer Adams

Aff565 Janssen Pharmaceutical R&D Spring House PA USA

Alexander Muik

3BioNTech SE, Mainz, Germany

Tahamtan Ahmadi

2Genmab A/S, Utrecht, Netherlands

Ugur Sahin

3BioNTech SE, Mainz, Germany

Oezlem Tuereci

9BioNTech SE, Mainz, Germany

Kristina Nuermberger

3BioNTech SE, Mainz, Germany

Angelica Sette

2Genmab, Utrecht, Netherlands

Monique Luijten

2Genmab, Utrecht, Netherlands

Maren Köhne

3BioNTech SE, Mainz, Germany

Jasja Wolthoorn

2Genmab, Utrecht, Netherlands

Sina Fellermeier-Kopf

3BioNTech SE, Mainz, Germany