Metastatic colorectal cancer. Evolution of treatment strategies: surgeons’ point of view

Abstract

This article explores evolution of treatment options in colorectal cancer with synchronous metastatic disease, role of surgical approach on different stages of combined‑modality therapy, including “liver first” strategy. Prospects of perioperative and neoadjuvant polychemotherapy in patients with colorectal cancer with synchronous distant metastases to liver, data on possibility of using radiation therapy in treatment of primary tumor and liver metastases, as well as risks and benefits of this approach and available clinical research data are analyzed.

Keywords

• colon cancer
• rectal cancer
• metastatic colorectal cancer
• neoadjuvant chemotherapy
• perioperative chemotherapy
• “liver first” strategy
• chemoradiation therapy
• synchronous metastases
• «liver first»