Two gates mediate NMDA receptor activity and are under subunit-specific regulation

Johansen B. Amin; Miaomiao He; Ramesh Prasad; Xiaoling Leng; Huan-Xiang Zhou; Lonnie P. Wollmuth

doi:10.1038/s41467-023-37260-y

Nature Communications (Mar 2023)

Two gates mediate NMDA receptor activity and are under subunit-specific regulation

Johansen B. Amin,
Miaomiao He,
Ramesh Prasad,
Xiaoling Leng,
Huan-Xiang Zhou,
Lonnie P. Wollmuth

Affiliations

Johansen B. Amin: Graduate Program in Cellular and Molecular Pharmacology, Stony Brook University
Miaomiao He: Graduate Program in Biochemistry and Structural Biology, Stony Brook University
Ramesh Prasad: Department of Chemistry, University of Illinois at Chicago
Xiaoling Leng: Department of Chemistry, University of Illinois at Chicago
Huan-Xiang Zhou: Department of Chemistry, University of Illinois at Chicago
Lonnie P. Wollmuth: Center for Nervous System Disorders, Stony Brook University

DOI: https://doi.org/10.1038/s41467-023-37260-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 11

Abstract

Read online

NMDA receptors are glutamate-gated ion channels that regulate fast signaling in the brain. Here, the authors show that the opening and closing patterns of the channel derive from the action of two gates that are regulated by distinct subunits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal