Nature Communications (Feb 2020)
A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction
- Laura Domingo-Rodriguez,
- Inigo Ruiz de Azua,
- Eduardo Dominguez,
- Eric Senabre,
- Irene Serra,
- Sami Kummer,
- Mohit Navandar,
- Sarah Baddenhausen,
- Clementine Hofmann,
- Raul Andero,
- Susanne Gerber,
- Marta Navarrete,
- Mara Dierssen,
- Beat Lutz,
- Elena Martín-García,
- Rafael Maldonado
Affiliations
- Laura Domingo-Rodriguez
- Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF)
- Inigo Ruiz de Azua
- Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz
- Eduardo Dominguez
- Centre for genomic regulation (CRG), The Barcelona Institute of Science and Technology
- Eric Senabre
- Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF)
- Irene Serra
- Instituto Cajal, CSIC
- Sami Kummer
- Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF)
- Mohit Navandar
- Faculty of Biology and Center of Computational Sciences, Johannes Gutenberg University
- Sarah Baddenhausen
- Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz
- Clementine Hofmann
- Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz
- Raul Andero
- Department of Psychobiology and Methodology in Health Sciences, Universitat Autònoma de Barcelona (UAB)
- Susanne Gerber
- Faculty of Biology and Center of Computational Sciences, Johannes Gutenberg University
- Marta Navarrete
- Instituto Cajal, CSIC
- Mara Dierssen
- Centre for genomic regulation (CRG), The Barcelona Institute of Science and Technology
- Beat Lutz
- Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz
- Elena Martín-García
- Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF)
- Rafael Maldonado
- Laboratory of Neuropharmacology-Neurophar, Department of Experimental and Health Sciences, Universitat Pompeu Fabra (UPF)
- DOI
- https://doi.org/10.1038/s41467-020-14458-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Food addiction is linked to obesity and eating disorders. In a mouse model of food addiction, the authors show that a medial prefrontal cortex-nucleus accumbens pathway is involved in vulnerability and resilience against the development of food addiction-like behavior.
