Effect of latanoprost combined with timolol treatment on visual function, intraocular pressure and ocular blood flow of open angle glaucoma

Abstract

AIM: To study the effect of latanoprost combined with timolol treatment on visual function, intraocular pressure and ocular blood flow of open angle glaucoma. METHODS:A total of 50 cases(59 eyes)with open angle glaucoma were enrolled from January 2012 to May 2014 in our hospital department of ophthalmology, and divided into observation group and control group by adopting the random number table method. Patients in observation group were treated with latanoprost combined with timolol, patients in control group were treated only with timolol. Visual function, intraocular pressure and ocular blood flow were compared. RESULTS: 1, 2, 3 and 4wk after treatment, observation group during the day intraocular pressure, night intraocular pressure were significantly lower than that in control group, vision levels(0.27±0.03, 0.36±0.06, 0.44±0.06, 0.63±0.13)were significantly higher than that in control group; observation group peak systolic velocity(14.41±1.73)cm/s, end diastolic velocity(4.18±0.67)cm/s were significantly higher than that in control group; vascular resistance index(0.58±0.07)was significantly lower than that in control group. CONCLUSION:Latanoprost combined with timolol treatment can reduce intraocular pressure, increase blood flow of central retinal artery, reduce vascular resistance, improve visual acuity.

Keywords

• open angle glaucoma
• latanoprost
• timolol
• intraocular pressure