Nature Communications (May 2021)
The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation
- Richard J. Acton,
- Wei Yuan,
- Fei Gao,
- Yudong Xia,
- Emma Bourne,
- Eva Wozniak,
- Jordana Bell,
- Karen Lillycrop,
- Jun Wang,
- Elaine Dennison,
- Nicholas C. Harvey,
- Charles A. Mein,
- Tim D. Spector,
- Pirro G. Hysi,
- Cyrus Cooper,
- Christopher G. Bell
Affiliations
- Richard J. Acton
- William Harvey Research Institute, Barts & The London School of Medicine and Dentistry, Charterhouse Square, Queen Mary University of London
- Wei Yuan
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital, King’s College London
- Fei Gao
- BGI-Shenzhen
- Yudong Xia
- BGI-Shenzhen
- Emma Bourne
- Barts & The London Genome Centre, Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London
- Eva Wozniak
- Barts & The London Genome Centre, Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London
- Jordana Bell
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital, King’s College London
- Karen Lillycrop
- Human Development and Health, Institute of Developmental Sciences, University of Southampton
- Jun Wang
- Shenzhen Digital Life Institute
- Elaine Dennison
- MRC Lifecourse Epidemiology Unit, University of Southampton
- Nicholas C. Harvey
- MRC Lifecourse Epidemiology Unit, University of Southampton
- Charles A. Mein
- Barts & The London Genome Centre, Blizard Institute, Barts & The London School of Medicine and Dentistry, Queen Mary University of London
- Tim D. Spector
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital, King’s College London
- Pirro G. Hysi
- Department of Twin Research & Genetic Epidemiology, St Thomas Hospital, King’s College London
- Cyrus Cooper
- MRC Lifecourse Epidemiology Unit, University of Southampton
- Christopher G. Bell
- William Harvey Research Institute, Barts & The London School of Medicine and Dentistry, Charterhouse Square, Queen Mary University of London
- DOI
- https://doi.org/10.1038/s41467-021-22639-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
The epigenome has been shown to change with age, potentially impacting on ageing-related disease. Here the authors investigate the DNA methylation state of the genomic loci of human tRNA and observe enrichment for age-related DNA hypermethylation at tRNA loci.
