Nature Communications (Feb 2023)
Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA
- Mark R. Davies,
- Nadia Keller,
- Stephan Brouwer,
- Magnus G. Jespersen,
- Amanda J. Cork,
- Andrew J. Hayes,
- Miranda E. Pitt,
- David M. P. De Oliveira,
- Nichaela Harbison-Price,
- Olivia M. Bertolla,
- Daniel G. Mediati,
- Bodie F. Curren,
- George Taiaroa,
- Jake A. Lacey,
- Helen V. Smith,
- Ning-Xia Fang,
- Lachlan J. M. Coin,
- Kerrie Stevens,
- Steven Y. C. Tong,
- Martina Sanderson-Smith,
- Jai J. Tree,
- Adam D. Irwin,
- Keith Grimwood,
- Benjamin P. Howden,
- Amy V. Jennison,
- Mark J. Walker
Affiliations
- Mark R. Davies
- Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Nadia Keller
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland
- Stephan Brouwer
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland
- Magnus G. Jespersen
- Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Amanda J. Cork
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland
- Andrew J. Hayes
- Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Miranda E. Pitt
- Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- David M. P. De Oliveira
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland
- Nichaela Harbison-Price
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland
- Olivia M. Bertolla
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland
- Daniel G. Mediati
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Bodie F. Curren
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland
- George Taiaroa
- Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Jake A. Lacey
- Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Helen V. Smith
- Public Health Microbiology, Queensland Health Forensic and Scientific Services, Queensland Health
- Ning-Xia Fang
- Public Health Microbiology, Queensland Health Forensic and Scientific Services, Queensland Health
- Lachlan J. M. Coin
- Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Kerrie Stevens
- Microbiological Diagnostic Unit Public Health Laboratory, The Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Steven Y. C. Tong
- Department of Infectious Diseases, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Martina Sanderson-Smith
- Illawarra Health and Medical Research Institute and Molecular Horizons, School of Chemistry and Molecular Bioscience, University of Wollongong
- Jai J. Tree
- School of Biotechnology and Biomolecular Sciences, University of New South Wales
- Adam D. Irwin
- University of Queensland Centre for Clinical Research
- Keith Grimwood
- School of Medicine and Dentistry and Menzies Health Institute Queensland, Griffith University
- Benjamin P. Howden
- Microbiological Diagnostic Unit Public Health Laboratory, The Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity
- Amy V. Jennison
- Public Health Microbiology, Queensland Health Forensic and Scientific Services, Queensland Health
- Mark J. Walker
- Australian Infectious Diseases Research Centre and School of Chemistry and Molecular Biosciences and Institute for Molecular Bioscience, The University of Queensland
- DOI
- https://doi.org/10.1038/s41467-023-36717-4
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 12
Abstract
A variant of group A Streptococcus serotype M1 (UK) has been increasingly reported and can be differentiated from the global variant by its overexpression of the superantigen SpeA. Here, Davies et al probe the mechanism behind enhanced SpeA expression and demonstrate that a SNP in the 5’ leader sequence of ssrA is responsible for this virulence phenotype.
