Nature Communications (Aug 2021)
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy
- Ruth Jinfen Chai,
- Hendrikje Werner,
- Peter Yiqing Li,
- Yin Loon Lee,
- Khaing Thet Nyein,
- Irina Solovei,
- Tuan Danh Anh Luu,
- Bhavya Sharma,
- Raju Navasankari,
- Martina Maric,
- Lois Yu En Sim,
- Ying Jie Loh,
- Edita Aliwarga,
- Jason Wen Long Cheong,
- Alexandre Chojnowski,
- Matias Ilmari Autio,
- Yu Haiyang,
- Kenneth Kian Boon Tan,
- Choong Tat Keng,
- Shi Ling Ng,
- Wei Leong Chew,
- Michael Ferenczi,
- Brian Burke,
- Roger Sik Yin Foo,
- Colin L. Stewart
Affiliations
- Ruth Jinfen Chai
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Hendrikje Werner
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Peter Yiqing Li
- Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore
- Yin Loon Lee
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Khaing Thet Nyein
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Irina Solovei
- Department of Biology II, Ludwig Maximilians University Munich
- Tuan Danh Anh Luu
- Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore
- Bhavya Sharma
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Raju Navasankari
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Martina Maric
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Lois Yu En Sim
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Ying Jie Loh
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Edita Aliwarga
- Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore
- Jason Wen Long Cheong
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Alexandre Chojnowski
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Matias Ilmari Autio
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Yu Haiyang
- Muscle and Cardiac Biophysics Laboratory, Lee Kong Chien School of Medicine, Nanyang Technological University
- Kenneth Kian Boon Tan
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Choong Tat Keng
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Shi Ling Ng
- Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore
- Wei Leong Chew
- Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)
- Michael Ferenczi
- Muscle and Cardiac Biophysics Laboratory, Lee Kong Chien School of Medicine, Nanyang Technological University
- Brian Burke
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- Roger Sik Yin Foo
- Cardiovascular Research Institute (CVRI), Yong Loo Lin School of Medicine, National University of Singapore
- Colin L. Stewart
- Skin Research Institute (SRIS), Agency for Science, Technology and Research (A*STAR)
- DOI
- https://doi.org/10.1038/s41467-021-24849-4
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Mutations in the LaminA gene are the second most common inherited cause of Dilated Cardiomyopathy, a major form of heart failure. Here the authors show that disruption of the nuclear protein SUN1 in cardiomyocytes, by AAV mediated transduction of a SUN1 inhibitor, significantly suppress cardiomyopathy progression, providing a potential therapeutic route to treat this disease.
