Nature Communications (Feb 2022)
T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10
- Vidhya M. Ravi,
- Nicolas Neidert,
- Paulina Will,
- Kevin Joseph,
- Julian P. Maier,
- Jan Kückelhaus,
- Lea Vollmer,
- Jonathan M. Goeldner,
- Simon P. Behringer,
- Florian Scherer,
- Melanie Boerries,
- Marie Follo,
- Tobias Weiss,
- Daniel Delev,
- Julius Kernbach,
- Pamela Franco,
- Nils Schallner,
- Christine Dierks,
- Maria Stella Carro,
- Ulrich G. Hofmann,
- Christian Fung,
- Roman Sankowski,
- Marco Prinz,
- Jürgen Beck,
- Henrike Salié,
- Bertram Bengsch,
- Oliver Schnell,
- Dieter Henrik Heiland
Affiliations
- Vidhya M. Ravi
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Nicolas Neidert
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Paulina Will
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Kevin Joseph
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Julian P. Maier
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Jan Kückelhaus
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Lea Vollmer
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Jonathan M. Goeldner
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Simon P. Behringer
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- Florian Scherer
- Faculty of Medicine, University of Freiburg
- Melanie Boerries
- Faculty of Medicine, University of Freiburg
- Marie Follo
- Faculty of Medicine, University of Freiburg
- Tobias Weiss
- Department of Neurology and Brain Tumor Center, University Hospital Zurich and University of Zurich
- Daniel Delev
- Department of Neurosurgery, RWTH University of Aachen
- Julius Kernbach
- Department of Neurosurgery, RWTH University of Aachen
- Pamela Franco
- Department of Neurosurgery, Medical Center-University of Freiburg
- Nils Schallner
- Faculty of Medicine, University of Freiburg
- Christine Dierks
- Faculty of Medicine, University of Freiburg
- Maria Stella Carro
- Department of Neurosurgery, Medical Center-University of Freiburg
- Ulrich G. Hofmann
- Department of Neurosurgery, Medical Center-University of Freiburg
- Christian Fung
- Department of Neurosurgery, Medical Center-University of Freiburg
- Roman Sankowski
- Faculty of Medicine, University of Freiburg
- Marco Prinz
- Faculty of Medicine, University of Freiburg
- Jürgen Beck
- Department of Neurosurgery, Medical Center-University of Freiburg
- Henrike Salié
- Faculty of Medicine, University of Freiburg
- Bertram Bengsch
- Faculty of Medicine, University of Freiburg
- Oliver Schnell
- Department of Neurosurgery, Medical Center-University of Freiburg
- Dieter Henrik Heiland
- Microenvironment and Immunology Research Laboratory, Medical Center-University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-022-28523-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The tumour microenvironment counteracts immune therapy in Glioblastomas. Authors show here, using spatially resolved and single cell transcriptomics, that dysfunctional T cells are induced by a myeloid cell subset via Interleukin-10 signalling, and inhibition of the downstream JAK/STAT pathway might restore glioblastoma immune therapy responsiveness.
