Nature Communications (Jan 2021)

Structure of a microtubule-bound axonemal dynein

  • Travis Walton,
  • Hao Wu,
  • Alan Brown

DOI
https://doi.org/10.1038/s41467-020-20735-7
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood. Here authors report a cryo-EM reconstruction of a three-headed axonemal dynein natively bound to doublet microtubules isolated from cilia which provides a framework to understand the roles of individual subunits.