A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer

Soudeh Ghafouri-Fard; Tayybeh Khoshbakht; Bashdar Mahmud Hussen; Mohammad Taheri; Mohammad Taheri; Majid Mokhtari

doi:10.3389/fonc.2021.777849

Frontiers in Oncology (Nov 2021)

A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer

Soudeh Ghafouri-Fard,
Tayybeh Khoshbakht,
Bashdar Mahmud Hussen,
Mohammad Taheri,
Mohammad Taheri,
Majid Mokhtari

Affiliations

Soudeh Ghafouri-Fard: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Tayybeh Khoshbakht: Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Bashdar Mahmud Hussen: Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq
Mohammad Taheri: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad Taheri: Institute of Human Genetics, Jena University Hospital, Jena, Germany
Majid Mokhtari: Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.3389/fonc.2021.777849
Journal volume & issue: Vol. 11

Abstract

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AFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP1-AS1 can sequester a number of cancer-related miRNAs, thus affecting activity of signaling pathways involved in cancer progression. Most of animal studies have confirmed that AFAP1-AS1 silencing can reduce tumor volume and invasive behavior of tumor cells in the xenograft models. Moreover, statistical analyses in the human subjects have shown strong correlation between expression levels of this lncRNA and clinical outcomes. In the present work, we review the impact of AFAP1-AS1 in the carcinogenesis.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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