Nature Communications (Sep 2022)

Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis

  • Nutan Chaudhari,
  • Alison D. Findlay,
  • Andrew W. Stevenson,
  • Tristan D. Clemons,
  • Yimin Yao,
  • Amar Joshi,
  • Sepidar Sayar,
  • Gordon Wallace,
  • Suzanne Rea,
  • Priyanka Toshniwal,
  • Zhenjun Deng,
  • Philip E. Melton,
  • Nicole Hortin,
  • K. Swaminathan Iyer,
  • Wolfgang Jarolimek,
  • Fiona M. Wood,
  • Mark W. Fear

DOI
https://doi.org/10.1038/s41467-022-33148-5
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 14

Abstract

Read online

Scars are a significant problem caused by excess collagen in the skin. Here the authors develop a topical drug that reduces collagen stability and leads to improved scar appearance and stiffness in preclinical models.