Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes

Fanny Lebreton; Vanessa Lavallard; Kevin Bellofatto; Romain Bonnet; Charles H. Wassmer; Lisa Perez; Vakhtang Kalandadze; Antonia Follenzi; Michel Boulvain; Julie Kerr-Conte; David J. Goodman; Domenico Bosco; Thierry Berney; Ekaterine Berishvili

doi:10.1038/s41467-019-12472-3

Nature Communications (Oct 2019)

Insulin-producing organoids engineered from islet and amniotic epithelial cells to treat diabetes

Fanny Lebreton,
Vanessa Lavallard,
Kevin Bellofatto,
Romain Bonnet,
Charles H. Wassmer,
Lisa Perez,
Vakhtang Kalandadze,
Antonia Follenzi,
Michel Boulvain,
Julie Kerr-Conte,
David J. Goodman,
Domenico Bosco,
Thierry Berney,
Ekaterine Berishvili

Affiliations

Fanny Lebreton: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva
Vanessa Lavallard: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva
Kevin Bellofatto: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva
Romain Bonnet: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva
Charles H. Wassmer: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva
Lisa Perez: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva
Vakhtang Kalandadze: Institute of Medical Research, Ilia State University
Antonia Follenzi: Department of Health Sciences, University of Oriental Piedmont
Michel Boulvain: Department of Gynecology and Obstetrics, Geneva University Hospitals and University of Geneva
Julie Kerr-Conte: INSERM U1190, Translational Research for Diabetes, University of Lille
David J. Goodman: Department of Nephrology, St Vincent’s Hospital
Domenico Bosco: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva
Thierry Berney: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva
Ekaterine Berishvili: Cell Isolation and Transplantation Center, Surgery, Geneva University Hospitals and University of Geneva

DOI: https://doi.org/10.1038/s41467-019-12472-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

Read online

Islet transplantation is a feasible approach to treat type I diabetes, however inflammation and poor vascularisation impair long-term engraftment. Here the authors show that incorporating human amniotic epithelial cells into islet organoids improves engraftment and function of organoids, through enhanced revascularisation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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