The association of interleukin-6 gene with obesity in patients with coronary artery disease

Abstract

The aim of this study was to estimate value of a polymorphic locus C-174G of interleukin-6 gene in obesity development in patients with coronary artery disease. Materials and methods. 222 patients with coronary artery disease and obesity were included in this study. The research of an allelic C-174G polymorphism of interleukin-6 gene was conducted by PCR method with electrophoretic detection of results with use of reactants SNP-EKSPRESS ("Sintol", Russian Federation). Results. Development of obesity in patients with coronary artery disease has been connected with G gene (odds ratio = 1.58, 95 % confidence interval = [1.12–2.24], χ2 = 6.9; р < 0.05) and G/G genotype (odd ratio = 1.98, 95 % confidence interval = [1.25–3.16], χ2 = 8.4; р < 0.05) polymorphic locus of C-174G of interleukin-6 gene. The genotype G/G was reliably more frequent in patients with coronary artery disease and stage III of obesity by 15.26 % and 8.45 %, than in patients with the accompanying I and II stages of obesity (р < 0.05). In it's turn, C/G genotype in patients with coronary artery disease and the III stage of obesity occurred 11.21 % less, than in patients with the I stages of obesity (р < 0.05). Allele C, G and genotype C/C had unreliable distribution in patients with coronary artery disease depending on obesity degree (р < 0.05). Conclusions. This study has shown that the allele of G and G/G genotype of polymorphic locus C-174G of interleukin-6 gene is associated with development and progression of obesity in patients with coronary artery disease.

Keywords

• myocardial ischemia
• obesity
• interleukin-6 gene